http://www.logitech.com/pub/techsup...ch/it221cht.exe
The iTouch 2.21 software resolves the following issues:
• System volume does not respond or acts erratic.

The iTouch software supports the following Multimedia applications:
• Windows CD Player
• Windows Media Player up to version 9.x
• MUSICMATCH(tm) versions 4.x up to 8.1
• RealOne Player
• Creative PlayCenter versions 1.5, 2.x and 3.0
• WinAmp 2.x and WinAmp 3
• Sonic CinePlayer versions 1.0 and 1.5
• PowerDVD 3.0, 4.0 and 5.0
• Intervideo WinDVD 2.x, 4.0 and 5.1
• Quick Time 6.0 and 6.4
• iTunes 4.1

Supported browsers:
• America OnLine 5.0 — 9.0
• Internet Explorer 4.0 — 6.0 SP1
• NetScape 4.6 - 7.0
• MSN Explorer
• MSN 8
• Opera 6.03 — 6.05